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Resources - Publications
Wischik Team: Seminal publications (1985 - 2010)
Listed alphabetically by the following categories. Asterisks indicate relative importance.
Links to downloadable PDF documents as available, links to journal sites or abstracts where available.
- Seminal Tau papers from its identification and structural analysis in PHFs to an understanding of tau aggregation and its prevention (1985 – 2000).
- Supporting studies on Tau in normal and pathological conditions (1990 – 2000).
- Pathological staging of Alzheimer’s disease and progression of neurofibrillary pathology and its importance in AD compared with b-amyloid pathology (1990 – 2001).
- Clinical and genetic studies; APOE; dementia with Lewy bodies; schizophrenia, Synuclein; Tau in renal dialysis patients’ brains; others (1994 – 2000).
- Recent articles, selected TauRx presentations and reviews (2005 – 2010).
| 1. Seminal Tau papers from its identification and structural analysis in PHFs to an understanding of tau aggregation and its prevention (1985 – 2000) |
Harrington, C.R., Mukaetova-Ladinska, E.B., Hills, R., Edwards, P.C., Montejo de Garcini, E., Novak, M. & Wischik, C.M. (1991) Measurement of distinct immunochemical presentations of tau protein in Alzheimer disease. Proceedings of the National Academy of Sciences, USA 88, 5842-5846.
http://www.pnas.org/content/88/13/5842.abstract?sid=0d23910b-cc49-4ac4-98dc-846481b43c30
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Lai, R.Y.K., Gertz, H.-J., Wischik, D.J., Xuereb, J.H., Mukaetova-Ladinska, E.B., Harrington, C.R., Edwards, P.C., Mena, R., Paykel, E.S., Brayne, C., Huppert, F.A., Roth, M. & Wischik, C.M. (1995) Examination of phosphorylated tau protein as a PHF-precursor at early stage Alzheimer's disease. Neurobiology of Aging 16, 433-445.
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T09-3Y6HHW5-
42&_user=152381&_coverDate=06%2F30%2F1995&_alid
=1318865311&_rdoc=5&_fmt=high&_orig=search&_cdi=4857&_sort
=r&_docanchor=&view=c&_ct=35&_acct=C000012638&_version=1&_urlVersion=0&_
userid=152381&md5=de1dc47e7e38621c056eb1dcb045f82e
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Wischik, C.M. & Crowther, R.A. (1986) Subunit structure of the Alzheimer tangle. British Medical Bulletin 42, 51-56.
http://bmb.oxfordjournals.org/cgi/content/abstract/42/1/51?maxtoshow=
&hits=10&RESULTFORMAT=1&andorexacttitle=and&andorexacttitleabs=and&andorexactfulltext
=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=
42&firstpage=51&resourcetype=HWCIT
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Wischik, C.M., Crowther, R.A., Stewart, M. & Roth, M. (1985) Subunit structure of paired helical filaments in Alzheimer's disease.Journal of Cell Biology 100, 1905-1912.
http://jcb.rupress.org/content/100/6/1905.abstract?sid=74b5b15a-9241-4a85-870e-28653656da5a
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Wischik, C.M., Edwards, P.C., Lai, R.Y.K., Gertz, H.-J., Xuereb, J.H., Paykel, E.S., Brayne, C., Huppert, F.A., Mukaetova-Ladinska, E.B., Mena R., Roth, M. & Harrington, C.R. (1995) Quantitative analysis of tau protein in paired helical filament preparations: implications for the role of tau protein phosphorylation in PHF assembly in Alzheimer’s disease. Neurobiology of Aging 16, 409-431.
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T09-3Y6HHW5-3X&_user=152381&_coverDate=06%2F30%2F1995&_alid=1319051461&_
rdoc=2&_fmt=high&_orig=search&_cdi=4857&_sort=r&_docanchor=&view=c&_ct=6&_
acct=C000012638&_version=1&_urlVersion=0&_userid=152381&md5=
c3eb2cf3cb6537115591f181ff9838f6
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Wischik, C.M., Edwards, P.C., Lai, R.Y.K., Roth, M. & Harrington, C.R. (1996) Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines. of the National Academy of Sciences Proceedings, USA 93, 11213-11218.
http://www.pnas.org/content/93/20/11213.abstract?sid=f94c3c18-155c-461a-be06-880e88394785
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Wischik, C.M., Lai, R.Y.K. & Harrington, C.R. (1997) Modelling prion-like processing of tau protein in Alzheimer’s disease for pharmaceutical development. In Microtubule-Associated Proteins: Modifications in Disease. (Eds. J. Avila, R. Brandt, & K. S. Kosik) Harwood Academic Publishers, Amsterdam, 185-241.
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Wischik, C.M., Novak, M., Edwards, P.C., Klug, A., Tichelaar, W. & Crowther, R.A. (1988) Structural characterization of the core of the paired helical filament of Alzheimer disease. Proceedings of the National Academy of Sciences, USA 85, 4884-4888.
http://www.pnas.org/content/85/13/4884.abstract?sid=2e0b6535-f421-41b0-8265-19b0eb6e639f
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Wischik, C.M., Novak, M., Thøgersen, H.C., Edwards, P.C., Runswick, M.J., Jakes, R., Walker, J.E., Milstein, C., M., R. & Klug, A. (1988) Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer's disease. Proceedings of the National Academy of Sciences, USA 85, 4506-4510.
http://www.pnas.org/content/85/12/4506.abstract?sid=3f0c2d69-7455-483e-aefa-
5f800bb8678b
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Wischik, C.M., Theuring, F. & Harrington, C.R. (2000) The molecular basis of tau protein pathology in Alzheimer's disease and related neurodegenerative dementias. In Neurobiology of Alzheimer’s Disease (Eds. D. Dawbarn & S. J. Allen) Oxford University Press, Oxford, 103-206.
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| 2. Supporting studies on Tau in normal and pathological conditions (1990 – 2000) |
Bondareff, W., Harrington, C.R., McDaniel, S.W., Wischik, C.M. & Roth, M. (1994) Presence of axonal paired helical filament tau in Alzheimer's disease: submicroscopic localization. Journal of Neuroscience Research 38, 664-669.
http://www3.interscience.wiley.com/journal/109697274/abstract
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Bondareff, W., Harrington, C.R., Wischik, C.M., Hauser, D.L. & Roth, M. (1995) Absence of abnormal hyperphosphorylation of tau in intracellular tangles in Alzheimer's disease. Journal of Neuropathology and Experimental Neurology 54, 657-663.
http://journals.lww.com/jneuropath/Abstract/1995/09000/
Absence_of_Abnormal_Hyperphosphorylation_of_Tau_in.7.aspx
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| 3. Pathological staging of Alzheimer’s disease and progression of neurofibrillary pathology and its importance in AD compared with b-amyloid pathology (1990 – 2001) |
Bondareff, W., Harrington, C., Wischik, C.M., Hauser, D.L. & Roth, M. (1994) Immunohistochemical staging of neurofibrillary degeneration in Alzheimer's disease. Journal of Neuropathology and Experimental Neurology 53, 158-164.
http://journals.lww.com/jneuropath/Abstract/1994/03000/
Immunohistochemical_Staging_of_Neurofibrillary.7.aspx
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Bondareff, W., Wischik, C.M., Novak, M., Amos, W.B., Klug, A. & Roth, M. (1990) Molecular analysis of neurofibrillary degeneration in Alzheimer's disease: an immunohistochemical study. American Journal of Pathology 137, 711-723.
http://ajp.amjpathol.org/cgi/content/abstract/137/3/711
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Garcia-Sierra, F., Hauw, J.J., Duyckaerts, C., Wischik, C.M., Luna-Muñoz, J. & Mena, R. (2000) The extent of neurofibrillary pathology in perforant pathway neurons is the key determinant of dementia in the very old. Acta Neuropathologica 100, 29-35.
http://www.springerlink.com/content/nhcdanmxx63yee2v/
?p=bf506832296845abbd4f267f55cb8910&pi=3
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García-Sierra, F., Wischik, C.M., Harrington, C.R., Luna-Muñoz, J. & Mena, R. (2001) Accumulation of C-terminally truncated tau protein associated with vulnerability of the perforant pathway in early stages of neurofibrillary pathology in Alzheimer’s disease. Journal of Chemical Neuroanatomy 22, 65-77.
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=
B6T02-43HSMT3-6&_user=152381&_coverDate=07%2F31%2F2001&_alid=1318865311&_rdoc=
9&_fmt=high&_orig=search&_cdi=4850&_sort=r&_docanchor=&view=
c&_ct=35&_acct=C000012638&_version=1&_urlVersion=
0&_userid=152381&md5=da3a2189d76f2390eb16cd9ded6e1c56
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Gertz, H.-J., Xuereb, J.H., Huppert, F.A., Brayne, C., Kuüger, H., McGee, M.A., Paykel, E.S., Harrington, C.R., Mukaetova-Ladinska, E.B., O’Connor, D.W. & Wischik, C.M. (1996) The relationship between clinical dementia and neuropathological staging (Braak) in a very elderly community sample. European Archives of Psychiatry and Clinical Neuroscience 246, 132-136.
http://www.springerlink.com/content/p66x1146p7g752w1/
?p=b1227acc56664b76953e2041f7dda649&pi=5
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Gertz, H.-J., Xuereb, J., Huppert, F., Brayne, C., McGee, M.A., Paykel, E., Harrington, C., Mukaetova-Ladinska, E., Arendt, T. & Wischik, C.M. (1998) Examination of the validity of the hierarchical model of neuropathological staging in normal aging and Alzheimer's disease. Acta Neuropathologica 95, 154-158.
http://www.springerlink.com/content/vfmylk48x0rmx5f7/
?p=d025e240b24f4421aeacd3eb91b875ff&pi=6
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Mena, R., Edwards, P., Pérez-Olvera, O. & Wischik, C.M. (1995) Monitoring pathological assembly of tau and b-amyloid proteins in Alzheimer's disease. Acta Neuropathologica 89, 50-56.
http://www.springerlink.com/content/k533658622127085/
?p=ce775016e14644d696fc485a8c8c223a&pi=8
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Mena, R., Edwards, P.C., Harrington, C.R., Mukaetova-Ladinska, E.B. & Wischik, C.M. (1996) Staging the pathological assembly of truncated tau protein into paired helical filaments in Alzheimer's disease. Acta Neuropathologica 91, 633-641.
http://www.springerlink.com/content/cr8amr3nd82m63mn/
?p=0e984fc3850742768dc5cbd35158a20d&pi=10
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Mukaetova-Ladinska, E.B., Garcia-Sierra, F., Hurt, J., Gertz, H.J., Xuereb, J.H., Hills, R., Brayne, C., Huppert, F.A., Paykel, E.S., McGee, M., Jakes, R., Honer, W.G., Harrington, C.R. & Wischik, C.M. (2000) Staging of cytoskeletal and b-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer’s disease. American Journal of Pathology 157, 623-636.
http://ajp.amjpathol.org/cgi/content/abstract/157/2/623
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Mukaetova-Ladinska, E.B., Harrington, C.R., Roth, M. & Wischik, C.M. (1993) Biochemical and anatomical redistribution of tau protein in Alzheimer's disease. American Journal of Pathology 143, 565-578.
http://ajp.amjpathol.org/cgi/content/abstract/143/2/565
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| 4. Clinical and genetic studies; APOE; dementia with Lewy bodies; schizophrenia, Synuclein; Tau in renal dialysis patients’ brains; others (1994 – 2000). |
Harrington, C.R., Louwagie, J., Rossau, R., Vanmechelen, E., Perry, R.H., Perry, E.K., Xuereb, J.H., Roth, M. & Wischik, C.M. (1994) Influence of apolipoprotein E genotype on senile dementia of the Alzheimer and Lewy body types. Significance for etiological theories of Alzheimer's disease. American Journal of Pathology 145, 1472-1484.
http://ajp.amjpathol.org/cgi/content/abstract/145/6/1472
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Harrington, C.R., Perry, R.H., Perry, E.K., Hurt, J., McKeith, I.G., Roth, M. & Wischik, C.M. (1994) Senile dementia of Lewy body type and Alzheimer type are biochemically distinct in terms of paired helical filaments and hyperphosphorylated tau protein. Dementia 5, 215-228.
http://content.karger.com/ProdukteDB/produkte.asp?
Aktion=Ausgabe&Ausgabe=233364&ProduktNr=224226
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Harrington, C.R., Wischik C.M., McArthur, F.K., Taylor, G.A., Edwardson, J.A. & Candy, J.M. (1994) Alzheimer's-disease-like changes in tau protein processing: association with aluminium accumulation in brains of renal dialysis patients. Lancet 343, 993-997.
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1B-49N3044-2K4&_user=152381&_coverDate=04%2F23%2F1994&_alid=1319078863&_
rdoc=1&_fmt=high&_orig=search&_cdi=4886&_sort=r&_docanchor=&view=c&_
ct=2&_acct=C000012638&_version=1&_urlVersion=0&_userid=152381&md5=569a9
a7a55706de79972eab7c5f0c757
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| 5. Recent articles, selected TauRx presentations and reviews (2005 – 2010). |
Luna-Munoz, J., Peralta-Ramirez, J., Chavez-Macias, L., Harrington, C.R., Wischik, C.M. & Mena, R. (2008) Thiazin red as a neuropathological tool for the rapid diagnosis of Alzheimer's disease in tissue imprints. Acta Neuropathologica 116, 507-515.
http://www.springerlink.com/content/r7u85103380m7275/
?p=20d7f285a5d54c0b892d6646d293c93b&pi=3
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Wischik, C.M., Bentham, P., Wischik, D.J. & Seng, K.M. (2008) O3-04-07: Tau aggregation inhibitor (TAI) therapy with remberTM arrests disease progression in mild and moderate Alzheimer's disease over 50 weeks. Alzheimer's and Dementia 4, T167. LINKS TO FULL ABSTRACT
http://www.sciencedirect.com/science/article/B7W6D-4T25XX0-K7/2/ae9f39f3a87905d8b0e6257d3fb7b040
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Harrington, C., Rickard, J.E., Horsley, D., Harrington, K.A., Hindley, K.P., Riedel, G., Theuring, F., Seng, K.M. & Wischik, C.M. (2008) O1-06-04: Methylthioninium chloride (MTC) acts as a Tau aggregation inhibitor (TAI) in a cellular model and reverses Tau pathology in transgenic mouse models of Alzheimer's disease. Alzheimer's and Dementia 4, T120-T121. LINKS TO FULL ABSTRACT
http://www.sciencedirect.com/science/article/B7W6D-4T25XX0-CP/2/92f26d5c74e1930bca1c3a071451fbbc
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Deiana, S., Harrington, C., Riedel, G., Seng, K.M. & Wischik, C.M. (2008) P2-428: Methylthioninium chloride versus rivastigmine and their co-administration efficacy in reversing scopolamine-induced cognitive deficits in a pharmacological mouse model of Alzheimer's disease. Alzheimer's and Dementia 4, T499. LINKS TO FULL ABSTRACT
http://www.sciencedirect.com/science/article/B7W6D-4T25XX0-1X2/2/ecf74f699a36e0c8c02c7bdc0903dbae
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Melis, V., Deiana, S., Zabke, C., Stamer, K., Harrington, C.R., Riedel, G., Theuring, F., Seng, K.M. & Wischik, C.M. (2008) P2-383: Reversal of spatial problem-solving cognitive deficit in a transgenic mouse line overexpressing the repeat domain of Tau by treatment with the Tau aggregation inhibitor methylthioninium chloride. Alzheimer's and Dementia 4, T485. LINKS TO FULL ABSTRACT
http://www.sciencedirect.com/science/article/B7W6D-4T25XX0-1VF/2/00d8e704866eed8df1db71117b35f8cas
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Murray, A.D., Staff, R.T., Ahearn, T.S., Bentham, P., Seng, K.M. & Wischik, C. (2008) P4-384: Tau Aggregation Inhibitor (TAI) therapy with remberTM changes glucose metabolism in the medial temporal lobes in mild and moderate Alzheimer's disease (AD). Alzheimer's and Dementia 4, T786. LINKS TO FULL ABSTRACT
http://www.sciencedirect.com/science/article/B7W6D-4T25XX0-336/2/3c591a2864ad300ba9b2ed92978af19c
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Staff, R.T., Ahearn, T.S., Murray, A.D., Bentham, P., Seng, K.M. & Wischik, C. (2008) P4-347: Tau aggregation inhibitor (TAI) therapy with remberTM arrests the trajectory of rCBF decline in brain regions affected by Tau pathology in mild and moderate Alzheimer's disease (AD). Alzheimer's and Dementia 4, T775. LINKS TO FULL ABSTRACT
http://www.sciencedirect.com/science/article/B7W6D-4T25XX0-31X/2/d21a5db62aa1c83e17f77dc21c5d4509
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Zabke, C., Dietze, S., Stamer, K., Rickard, J.E., Harrington, C.R., Theuring, F., Seng, K.M. & Wischik, C.M. (2008) P1-054: Early and advanced stages of Tau aggregation in transgenic mouse models. Alzheimer's and Dementia 4, T221-T222. LINKS TO FULL ABSTRACT http://www.sciencedirect.com/science/article/B7W6D-4T25XX0-TP/2/4b4f89039e739c71106362dcd658780a
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Wischik, C. (2009) Rember: Issues in design of a phase 3 disease modifying clinical trial of Tau aggregation inhibitor therapy in Alzheimer's disease. Alzheimers & Dementia 5, P74.
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Luna-Muñoz, J., Peralta-Ramirez, J., Harrington, C.R., Wischik, C.M. & Mena, R. (2009) In pre-tangle cells truncation at Asp-421 along the C-terminus of tau protein appears to precede that of the Glu-391 in Alzheimer´s disease. Alzheimers & Dementia 5, P403. LINKS TO FULL ABSTRACT
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7W6D-4WKTN0Y-1M
M&_user=152381&_coverDate=07%2F31%2F2009&_alid=1319076437&_rdoc=1&_fmt=high&_orig=search
&_cdi=28548&_sort=r&_docanchor=&view=c&_ct=4&_acct=C000012638&_version=1&_url
Version=0&_userid=152381&md5=3f71097b4a88d1d000144d0196236b7a
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Melis, V., Zabke, C., Harrington, C.R., Theuring, F., Wischik, C.M. & Riedel, G. (2009) Age-related impairments in Tau transgenic mice using two different water maze training protocols Alzheimers & Dementia 5, P441-442. LINKSTO FULL ABSTRACT
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7W6D-4WKTN0Y-1T8&
_user=152381&_coverDate=07%2F31%2F2009&_alid=1319071883&_rdoc=4&_fmt=high&_orig
=search&_cdi=28548&_sort=r&_docanchor=&view=c&_ct=6&_acct=C000012638&_v
ersion=1&_urlVersion=0&_userid=152381&md5=3c2c7da1ab2d8b0c5175a247caab632c
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Zabke, C., Dietze, S., Melis, V., Stamer, K., Riedel, G., Harrington, C.R., Wischik, C.M. & Theuring, F. (2009) P4-039 - Overexpression of mutant tau in mice leads to tau aggregation and deterioration of motor skills Alzheimers & Dementia 5, P442-443. LINK TO FULL ABSTRACT
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7W6D-4WKTN0Y-1
TC&_user=152381&_coverDate=07%2F31%2F2009&_alid=1319071883&_rdoc=6&_fmt=high&
_orig=search&_cdi=28548&_sort=r&_docanchor=&view=c&_ct=6&_acct=C000012638&_version=
1&_urlVersion=0&_userid=152381&md5=1230e6508cbd73079ae3ca5e923ae185
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Deiana, S., Harrington, C.R., Wischik, C.M. & Riedel, G. (2009) Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine. Psychopharmacology 202, 53-65.
http://www.springerlink.com/content/qx87521g054142u7/?p=29ec491d
79fc4096a58d7c88fa20e9ab&pi=4
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Wischik, C. & Staff, R. (2009) Challenges in the conduct of disease-modifying trials in Alzheimer's disease: practical experience from a phase 2 trial of TAU-aggregation inhibitor therapy. Journal of Nutrition Health and Aging 13, 367-369.
http://www.springerlink.com/content/628811n3382j6444/?p=87381c7b9a5d4716a7b1dae38a0bf0c1&pi=21
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Wischik, C.M., Wischik, D.J., Storey, J.M.D. & Harrington, C.R. 2010. Rationale for tau aggregation inhibitor therapy in Alzheimer's disease and other tauopathies. In Emerging drugs and targets for Alzheimer's disease. Volume 1: ß-Amyloid, Tau Protein and Glucose Metabolism, ed. A. Martinez. pp. 210-232. RSC Drug Discovery Series Cambridge: Royal Society of Chemistry
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